Package index • Certara.Xpose.NLME

Creating Xpose Data Objects from NLME Output

Use these functions to import and transform output files from NLME runs in RsNLME or Phoenix into Xpose data objects, enabling streamlined visualization and analysis of model results.

xposeNlme(): Creates xpose database from Certara.RsNLME output files
xposeNlmeModel(): Creates xpose database from Certara.RsNLME objects

Plotting Functions

These functions to extend capabilities in the xpose package for plotting covariate models.

eta_vs_cov(): ETAs vs covariate Plot
prm_vs_cov(): Parameter vs covariate Plot
res_vs_cov(): Residuals vs covariate plot
xplot_box(): Default xpose box plot function
nlme.ranpar.vs.cov(): Plot random parameter estimates against covariates
nlme.par.vs.cov(): Plot parameter estimates against covariates
nlme.var.vs.cov(): Build multiple plots for selected variable vs covariates
nlme.cov.splom(): Create covariates scatterplot

Get summary data

Use these functions to extract information from the xpose_data object for table generation.

get_overallNlme(): Access NLME model overall fit results
get_prmNlme(): Access NLME model parameter estimates
get_summaryNlme() print(<summaryNlme>): Build a parameter summary table for an NLME xpdb
get_bootSummaryNlme() print(<bootSummaryNlme>): Build a fused fit + bootstrap parameter summary

ETA shrinkage

Inspect subject-level ETA estimates and recompute overall ETA shrinkage after filtering out subjects whose individual shrinkage is close to 1.

get_etaSubjectNlme(): Access subject-level ETA data
compare_etaShrinkageNlme(): Compare original and filtered ETA shrinkage
update_etaShrinkageNlme(): Update ETA shrinkage with subject-level filtering

Parameter estimate tables

Build single- and multi-model parameter estimate tables ready for reporting.

compare_prmNlme(): Compare NLME parameter estimates across multiple runs
as_flextable(<prmComparisonNlme>): Render a parameter comparison as a flextable

Example data

xpdb_ex_Nlme: XposeNlme example xpose_data object

Certara.R MCP integration

Tool builder used by the Certara.R MCP host. Not intended to be called directly.

xpose_mcp_tools(): Build the Certara.Xpose.NLME MCP tool set