Use to create a PK model

pkmodel(
isPopulation = TRUE,
parameterization = "Clearance",
absorption = "Intravenous",
numCompartments = 1,
isClosedForm = TRUE,
isTlag = FALSE,
hasEliminationComp = FALSE,
isFractionExcreted = FALSE,
isSaturating = FALSE,
infusionAllowed = FALSE,
isDuration = FALSE,
isStdevFrozen = FALSE,
data = NULL,
ID = NULL,
Time = NULL,
A1 = NULL,
Aa = NULL,
A = NULL,
A1_Rate = NULL,
A1_Duration = NULL,
Aa_Rate = NULL,
Aa_Duration = NULL,
A_Rate = NULL,
A_Duration = NULL,
A1Strip = NULL,
CObs = NULL,
C1Obs = NULL,
A0Obs = NULL,
columnMap = TRUE,
modelName = "",
workingDir = ""
)

## Arguments

isPopulation Is this a population model TRUE or individual model FALSE? Type of parameterization. Options are "Clearance", "Micro", "Macro", or "Macro1". Type of absorption. Options are "Intravenous", "FirstOrder", "Gamma", "InverseGaussian", "Weibull" . Value of either 1, 2, or 3. Set to TRUE to convert model from a differential equation to close form. Set to TRUE to add a lag time parameter to the model. Set to TRUE to add an elimination compartment to the model. Set to TRUE if elimination compartment (hasEliminationComp = TRUE) contains a fraction excreted parameter. Set to TRUE to use Michaelis-Menten kinetics for elimination. Only applicable to models with paramteterization = "Clearance" Set to TRUE if infusions allowed. Set to TRUE if infusions use duration instead of rate (must also set infusionAllowed = TRUE). Set to TRUE to freeze value of standard deviation of residual error variable. Input dataset Column mapping argument for input dataset column(s) that identify individual data profiles. Only applicable to population models isPopulation = TRUE. Column mapping argument that represents the input dataset column for the relative time used in a study and only applicable to time-based models. Column mapping argument that represents the input dataset column for the amount of drug administered. Only applicable to the following types of models: Models with absorption = "Intravenous" and parameterization set to either "Clearance","Micro", or "Macro" Models with absorption set to either "Gamma", "InverseGaussian", or "Weibull" Column mapping argument that represents the input dataset column for the amount of drug administered and only applicable to models with absorption = "FirstOrder". Column mapping argument that represents the input dataset column for the amount of drug administered and only applicable to models with absorption = "Intravenous" and parameterization = "Macro1". Column mapping argument that represents the input dataset column for the rate of drug administered. Only applicable to the following types of models: Models with absorption = "Intravenous", infusionAllowed = TRUE and parameterization set to either "Clearance","Micro" or "Macro" Models with absorption set to either "Gamma", "InverseGaussian", or "Weibull" and infusionAllowed = TRUE Column mapping argument that represents the input dataset column for the duration of drug administered. Only applicable to the following types of models: Models with absorption = "Intravenous", infusionAllowed = TRUE with isDuration = TRUE and parameterization set to either "Clearance","Micro" or "Macro" Models with absorption set to either "Gamma", "InverseGaussian", or "Weibull" and infusionAllowed = TRUE with isDuration = TRUE Column mapping argument that represents the input dataset column for the rate of drug administered and only applicable to models with absorption = "FirstOrder", infusionAllowed = TRUE. Column mapping argument that represents the input dataset column for the duration of drug administered and only applicable to models with absorption = "FirstOrder", infusionAllowed = TRUE, and isDuration = TRUE. Column mapping argument that represents the input dataset column for the rate of drug administered and only applicable to models with absorption = "Intravenous", infusionAllowed = TRUE, and parameterization = "Macro1". Column mapping argument that represents the input dataset column for the duration of drug administered and only applicable to models with absorption = "Intravenous", infusionAllowed = TRUE, isDuration = TRUE, and parameterization = "Macro1". Column mapping argument that represents the input dataset column for the stripping dose and only applicable to models with parameterization = "Macro". Column mapping argument that represents the input dataset column for the observations of drug concentration in the central compartment and only applicable to models with parameterization being either set to either "Clearance" or "Micro". Column mapping argument that represents the input dataset column for the observations of drug concentration in the central compartment and only applicable to models with parameterization being either set to either "Macro" or "Macro1". Column mapping argument that represents the input dataset column for the observed amount of drug in the elimination compartment. (hasEliminationComp = TRUE). If TRUE (default) column mapping arguments are required. Set to FALSE to manually map columns after defining model using colMapping. Model name for subdirectory created for model output in current working directory. Working directory to run the model. Current working directory will be used if workingDir not specified.

## Examples

if (FALSE) {
model <- pkmodel(parameterization = "Clearance",
numCompartments=2,
data = pkData,
ID = "Subject",
Time = "Act_Time",
A1 = "Amount",
CObs = "Conc")

# View the model as well as its associated column mappings
print(model)
}