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Sets or updates the covariance matrix of random effects

randomEffect.Rd

Use to set or update the covariance matrix of random effects in a model object.

Usage

randomEffect(
  .Object,
  effect,
  value = NULL,
  isDiagonal = TRUE,
  isFrozen = FALSE,
  ...
)

Arguments

.Object

Model object

effect

One or more names of available random effects.

value

Initial values for the diagonal elements of the covariance matrix of random effects (if isDiagonal = TRUE, or initial values for the lower triangular elements (including diagonal elements) of the covariance matrix (if isDiagonal = FALSE) in a row-wise order.

isDiagonal

Set to TRUE to if the covariance matrix of the specified random effects is a diagonal matrix. or FALSE if not.

isFrozen

Set to TRUE to freeze the covariance matrix of random effects.

...

Additional arguments

Value

Modified NlmePmlModel object

Examples

model <- pkmodel(
  numCompartments = 2,
  data = pkData,
  ID = "Subject",
  Time = "Act_Time",
  A1 = "Amount",
  CObs = "Conc",
  modelName = "TwCpt_IVBolus_FOCE_ELS",
  workingDir = tempdir()
  )

model <-
  randomEffect(model,
               effect = c("nV", "nCl", "nCl2"), value = rep(0.1, 3))