PK Indirect model mapping parameters

PK Indirect mapping parameters

pkindirectmodel_MappingParameters(
  ID = NULL,
  Time = NULL,
  A1 = NULL,
  Aa = NULL,
  A = NULL,
  A1_Rate = NULL,
  A1_Duration = NULL,
  Aa_Rate = NULL,
  Aa_Duration = NULL,
  A_Rate = NULL,
  A_Duration = NULL,
  A1Strip = NULL,
  CObs = NULL,
  C1Obs = NULL,
  A0Obs = NULL,
  EObs = NULL,
  nV = NULL,
  nV2 = NULL,
  nV3 = NULL,
  nCl = NULL,
  nCl2 = NULL,
  nCl3 = NULL,
  nKa = NULL,
  nA = NULL,
  nAlpha = NULL,
  nB = NULL,
  nBeta = NULL,
  nC = NULL,
  nGamma = NULL,
  nKe = NULL,
  nK12 = NULL,
  nK21 = NULL,
  nK13 = NULL,
  nK31 = NULL,
  nTlag = NULL,
  nKm = NULL,
  nVmax = NULL,
  nFe = NULL,
  nMeanDelayTime = NULL,
  nShapeParamMinusOne = NULL,
  nShapeParam = NULL
)

Arguments

ID

Column mapping argument for input dataset column(s) that identify individual data profiles. Only applicable to population models isPopulation = TRUE.

Time

Column mapping argument that represents the input dataset column for the relative time used in a study and only applicable to time-based models.

A1

Column mapping argument that represents the input dataset column for the amount of drug administered. Only applicable to the following types of models:

  • Models with absorption = "Intravenous" and parameterization set to either "Clearance","Micro", or "Macro"

  • Models with absorption set to either "Gamma", "InverseGaussian", or "Weibull"

Aa

Column mapping argument that represents the input dataset column for the amount of drug administered and only applicable to models with absorption = "FirstOrder".

A

Column mapping argument that represents the input dataset column for the amount of drug administered and only applicable to models with absorption = "Intravenous" and parameterization = "Macro1".

A1_Rate

Column mapping argument that represents the input dataset column for the rate of drug administered. Only applicable to the following types of models:

  • Models with absorption = "Intravenous", infusionAllowed = TRUE and parameterization set to either "Clearance","Micro" or "Macro"

  • Models with absorption set to either "Gamma", "InverseGaussian", or "Weibull" and infusionAllowed = TRUE

A1_Duration

Column mapping argument that represents the input dataset column for the duration of drug administered. Only applicable to the following types of models:

  • Models with absorption = "Intravenous", infusionAllowed = TRUE with isDuration = TRUE and parameterization set to either "Clearance","Micro" or "Macro"

  • Models with absorption set to either "Gamma", "InverseGaussian", or "Weibull" and infusionAllowed = TRUE with isDuration = TRUE

Aa_Rate

Column mapping argument that represents the input dataset column for the rate of drug administered and only applicable to models with absorption = "FirstOrder", infusionAllowed = TRUE.

Aa_Duration

Column mapping argument that represents the input dataset column for the duration of drug administered and only applicable to models with absorption = "FirstOrder", infusionAllowed = TRUE, and isDuration = TRUE.

A_Rate

Column mapping argument that represents the input dataset column for the rate of drug administered and only applicable to models with absorption = "Intravenous", infusionAllowed = TRUE, and parameterization = "Macro1".

A_Duration

Column mapping argument that represents the input dataset column for the duration of drug administered and only applicable to models with absorption = "Intravenous", infusionAllowed = TRUE, isDuration = TRUE, and parameterization = "Macro1".

A1Strip

Column mapping argument that represents the input dataset column for the stripping dose and only applicable to models with parameterization = "Macro".

CObs

Column mapping argument that represents the input dataset column for the observations of drug concentration in the central compartment and only applicable to models with parameterization being either set to either "Clearance" or "Micro".

C1Obs

Column mapping argument that represents the input dataset column for the observations of drug concentration in the central compartment and only applicable to models with parameterization being either set to either "Macro" or "Macro1".

A0Obs

Column mapping argument that represents the input dataset column for the observed amount of drug in the elimination compartment. (hasEliminationComp = TRUE).

EObs

Column mapping argument that represents the input dataset column for the observed drug effect.

nV

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nV.

nV2

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nV2.

nV3

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nV3.

nCl

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nCl.

nCl2

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nCl2.

nCl3

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nCl3.

nKa

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nKa.

nA

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nA.

nAlpha

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nAlpha.

nB

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nB.

nBeta

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nBeta.

nC

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nC.

nGamma

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nGamma.

nKe

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nKe.

nK12

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nK12.

nK21

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nK21.

nK13

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nK13.

nK31

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nK31.

nTlag

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nTlag.

nKm

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nKm.

nVmax

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nVmax.

nFe

If isSequential = TRUE and isFractionExcreted = TRUE, mapped to the input dataset column that lists the values for random effect nFe.

nMeanDelayTime

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nMeanDelayTime.

nShapeParamMinusOne

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nShapeParamMinusOne.

nShapeParam

If isSequential = TRUE, mapped to the input dataset column that lists the values for random effect nShapeParam.