Setup and Configuration

System Requirements

Windows 10
Simcyp^TM Simulator v23 installation and license
R >= 4.3.2

Installation

Prior to using Simcyp^TM VBE in Pirana, the following installation and configuration steps should be completed.

Install Simcyp Simulator v23

Contact simcyp.support@certara.com to request Simcyp^TM Simulator V23.

Install Simcyp R package and dependencies

The Simcyp^TM R package is distributed from Simcyp^TM support via a download link and can be requested from simcyp.support@certara.com.

The Simcyp^TM R package requires additional package dependencies, which can first be installed from CRAN using the following command:

install.packages(c("Rcpp", "XML", "xml2", "RcppThread", "R.utils", "RSQLite", "DBI", "rlang", "tibble", "fs", "PKNCA", "dplyr", "stringr", "ggplot2", "pracma"))

After dependencies are successully installed, download the package archive file from the Simcyp^TM download portal and install the package binary file. Steps for doing this in RStudio are outlined below.

1.) From RStudio, navigate to Tools > Install Packages.

2.) In the Install from: dropdown selection, change to Package archive file and select the Simcyp^TM R package .zip file in your file explorer.

The current Released Version of the Simcyp R package is Simcyp_23.0.64.zip.

Install `Certara.SimcypVBE` R package

The Certara.SimcypVBE R package contains the Shiny application used to perform Simcyp^TM VBE analysis and can be installed from Certara’s internal CRAN repository using the command below.

install.packages( 
  "Certara.SimcypVBE", 
  repos = c("https://certara.jfrog.io/artifactory/certara-cran-release-public/",  
  "https://cloud.r-project.org"),
  method = "libcurl")

Configuration

Before configuring Pirana settings, navigate to Help > License > Login. You will be redirected to Certara’s CAD Online Licensing System to login and verify Pirana license.

Open Pirana and navigate to File > Settings. Select the ‘Software Integration’ tab on the left and populate the fields highlighted in yellow e.g., R location, RStudio location, and Simcyp^TM simulator. When finished, select ‘Save and Close’.